E-Cigarette Exposure Decreases Bone Marrow Hematopoietic Progenitor Cells.

ABSTRACT: Electronic cigarettes (E-cigs) generate nicotine containing aerosols for inhalation and have emerged as a popular tobacco product among adolescents and young adults, yet little is known about their health effects due to their relatively recent introduction. Few studies have assessed the long-term effects of inhaling E-cigarette smoke or vapor. Here, we show that two months of E-cigarette exposure causes suppression of bone marrow hematopoietic stem and progenitor cells (HSPCs). Specifically, the common myeloid progenitors and granulocyte-macrophage progenitors were decreased in E-cig exposed animals compared to air exposed mice. Competitive reconstitution in bone marrow transplants was not affected by two months of E-cig exposure. When air and E-cig exposed mice were challenged with an inf

SUBMITTER: Ramanathan G 

PROVIDER: S-EPMC7464997 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature