Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells.

ABSTRACT: Type 1 diabetes (T1DM) is a chronic autoimmune disease, with a strong genetic background, leading to a gradual loss of pancreatic beta-cells, which secrete insulin and control glucose homeostasis. Patients with T1DM require life-long substitution with insulin and are at high risk for development of severe secondary complications. The incidence of T1DM has been continuously growing in the last decades, indicating an important contribution of environmental factors. Accumulating data indicates that sphingolipids may be crucially involved in T1DM development. The serum lipidome of T1DM patients is characterized by significantly altered sphingolipid composition compared to nondiabetic, healthy probands. Recently, several polymorphisms in the genes encoding the enzymatic machinery for sphingolip

SUBMITTER: Gurgul-Convey E 

PROVIDER: S-EPMC7465050 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature