A Multi-Analyte Approach for Improved Sensitivity of Liquid Biopsies in Prostate Cancer.

ABSTRACT: Novel androgen receptor (AR) signaling inhibitors have improved the treatment of castration-resistant prostate cancer (CRPC). Nonetheless, the effect of these drugs is often time-limited and eventually most patients become resistant due to various AR alterations. Although liquid biopsy approaches are powerful tools for early detection of such therapy resistances, most assays investigate only a single resistance mechanism. In combination with the typically low abundance of circulating biomarkers, liquid biopsy assays are therefore informative only in a subset of patients. In this pilot study, we aimed to increase overall sensitivity for tumor-related information by combining three liquid biopsy approaches into a multi-analyte approach. In a cohort of 19 CRPC patients, we (1) enumerated and

SUBMITTER: Hofmann L 

PROVIDER: S-EPMC7465186 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature