Co-Amorphization of Kanamycin with Amino Acids Improves Aerosolization.

ABSTRACT: Different formulation techniques have been investigated to prepare highly aerosolizable dry powders to deliver a high dose of antibiotics to the lung for treating local infections. In this study, we investigated the influence of the co-amorphization of a model drug, kanamycin, with selected amino acids (valine, methionine, phenylalanine, and tryptophan) by co-spray drying on its aerosolization. The co-amorphicity was confirmed by thermal technique. The physical stability was monitored using low-frequency Raman spectroscopy coupled with principal component analysis. Except for the kanamycin-valine formulation, all the formulations offered improved fine particle fraction (FPF) with the highest FPF of 84% achieved for the kanamycin-methionine formulation. All the co-amorphous formulations wer

SUBMITTER: Adhikari BR 

PROVIDER: S-EPMC7465208 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature