Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone Metastases.

ABSTRACT: Bone metastasis is a major cause of morbidity within solid tumours of the breast, prostate, lung and kidney. Metastasis to the skeleton is associated with a wide range of complications including bone fractures, spinal cord compression, hypercalcaemia and increased bone pain. Improved treatments for bone metastasis, such as the use of anti-bone resorptive bisphosphonate agents, within post-menopausal women have improved disease-free survival; however, these treatments are not without side effects. There is thus a need for biomarkers, which will predict the risk of developing the spread to bone within these cancers. The application of molecular profiling techniques, together with animal model systems and engineered cell-lines has enabled the identification of a series of potential bone-metas

SUBMITTER: Wood SL 

PROVIDER: S-EPMC7465268 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature