Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery.

ABSTRACT: Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues. Proliposomes are one of the formulation approaches for achieving solid powders that readily form liposomes upon hydration. In this work, we investigated a dry powder formulation of a model low-soluble drug with phospholipids loaded in porous functionalized calcium carbonate microparticles. We characterized the liposome formation under conditions that mimic the different gastrointestinal stages and studied the factors that influence the dissolution rate of the model drug. The liposomes that formed upon direct contact with the simulated gastric environment had a capacity to directly encapsulate 25% of the drug in si

SUBMITTER: Farzan M 

PROVIDER: S-EPMC7465306 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature