Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_circ_0044556 in the progression of colorectal cancer (CRC) remains unclear.

Methods

First, we searched for differentially expressed circRNAs using a circRNA microarray in paired CRC and adjacent normal tissues. The circRNA hsa_circ_0044556 was screened out from the existing CRC circRNA microarray in the Gene Expression Omnibus database and our microarray. The clinical significance of hsa_circ_0044556 expression level in CRC patients was then investigated. Finally, the functions of the targets of this circRNA were determined in CRC cell lines.

Results

Hsa

SUBMITTER: Jing L 

PROVIDER: S-EPMC7465356 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature