Value of metalloproteinases in predicting COPD in heavy urban smokers.

ABSTRACT:

Background

Emphysema in asymptomatic heavy smokers can be detected during CT-scan screening for lung cancer. Metalloproteinases (MMPs) have been found to play a role in the pathogenesis of chronic obstructive pulmonary disease and to possibly serve as biomarkers for emphysema.

Methods

The NYU Lung Cancer Biomarker Center enrolled study subjects over 50 years of age with lung cancer risk factors from January 1, 2010, to December 31, 2015. These subjects received chest multi-detector computed tomography, spirometry, and provided serum for immunoassays for metalloproteinases (MMP) -1, -2, -7, -9, -10 and tissue inhibitor of metalloproteinases (TIMP) -1 and -2.

Results

Three hundred sixteen study subjects were enrolled. Of the 222 patients who met the inclusion criteria,

SUBMITTER: Tsay JJ 

PROVIDER: S-EPMC7465798 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature