Quantifying the Landscape and Transition Paths for Proliferation-Quiescence Fate Decisions.

ABSTRACT: The cell cycle, essential for biological functions, experiences delicate spatiotemporal regulation. The transition between G1 and S phase, which is called the proliferation-quiescence decision, is critical to the cell cycle. However, the stability and underlying stochastic dynamical mechanisms of the proliferation-quiescence decision have not been fully understood. To quantify the process of the proliferation-quiescence decision, we constructed its underlying landscape based on the relevant gene regulatory network. We identified three attractors on the landscape corresponding to the G0, G1, and S phases, individually, which are supported by single-cell data. By calculating the transition path, which quantifies the potential barrier, we built expression profiles in temporal order for key re

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7466041 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature