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ABSTRACT:
SUBMITTER: Kobayashi M
PROVIDER: S-EPMC7466098 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Kobayashi Masaya M Kuzuyama Tomohisa T
Biomolecules 20200805 8
Structurally diverse carbazole alkaloids are valuable due to their pharmaceutical properties and have been isolated from nature. Experimental knowledge on carbazole biosynthesis is limited. The latest development of in silico analysis of the biosynthetic gene clusters for bacterial carbazoles has allowed studies on the biosynthesis of a carbazole skeleton, which was established by sequential enzyme-coupling reactions associated with an unprecedented carbazole synthase, a thiamine-dependent enzym ...[more]