Core-Shell Magnetic Nanoparticles for Highly Sensitive Magnetoelastic Immunosensor.

ABSTRACT: A magnetoelastic (ME) biosensor for wireless detection of analytes in liquid is described. The ME biosensor was tested against human IgG in the range 0-20 μg∙mL-1. The sensing elements, anti-human IgG produced in goat, were immobilized on the surface of the sensor by using a recently introduced photochemical immobilization technique (PIT), whereas a new amplification protocol exploiting gold coated magnetic nanoparticles (core-shell nanoparticles) is demonstrated to significantly enhance the sensitivity. The gold nanoflowers grown on the magnetic core allowed us to tether anti-human IgG to the nanoparticles to exploit the sandwich detection scheme. The experimental results show that the 6 mm × 1 mm × 30 μm ME biosensor with an amplification protocol that uses magnetic nanoparticles has a l

SUBMITTER: Campanile R 

PROVIDER: S-EPMC7466411 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature