Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection.

ABSTRACT:

Background

Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. This study investigated the potential role of Tfh cells in peripheral blood mononuclear cells (PBMCs) from children with acute MeV infection.

Results

The frequencies of CXCR5⁺CD4⁺ Tfh, ICOS^high Tfh, and PD-1^high Tfh cells in PBMCs and levels of IL-6 and IL-21 in plasma were significantly elevated in patients with acute MeV infection. Moreover, a positive correlation was discovered among the frequency of ICOS^high Tfh cells, plasma levels of IL-21

SUBMITTER: Shen W 

PROVIDER: S-EPMC7466526 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature