Variation in Tacrolimus Trough Concentrations in Liver Transplant Patients Undergoing Endoscopic Retrograde Cholangiopancreatography: A Retrospective, Observational Study.

ABSTRACT:

Objective

High variabilities in tacrolimus (TAC) exposure are still problems that confuse physicians. TAC trough levels (TAC C_min) fluctuated considerably after endoscopic retrograde cholangiopancreatography (ERCP) treatment in several liver transplant (LT) patients. We aimed to investigate the variation regularity of TAC C_min post-ERCP and related factors.

Methods

This study was a retrospective, observational study conducted at the First Affiliated Hospital of Zhejiang University in China. From October 2017 to January 2019, 26 LT patients that received ERCP were included (73 TAC C_min measures). The absolute difference and the variation extent in TAC C_min pre- and post-ERCP were analyzed. Patients were divided into mild and obvious

SUBMITTER: Wang R 

PROVIDER: S-EPMC7466563 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature