Effects of Ketamine Administration on Auditory Information Processing in the Neocortex of Nonhuman Primates.

ABSTRACT: Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exerts broad effects on consciousness and perception. Since NMDA receptor antagonists induce cognitive impairments, ketamine has been used for translational research on several psychiatric diseases, such as schizophrenia. Whereas the effects of ketamine on cognitive functions have been extensively studied, studies on the effects of ketamine on simple sensory information processing remain limited. In this study, we investigated the cortex-wide effects of ketamine administration on auditory information processing in nonhuman primates using whole-cortical electrocorticography (ECoG). We first recorded ECoG from awake monkeys on presenting auditory stimuli of different frequencies or different durations. We observed auditory evoked

SUBMITTER: Komatsu M 

PROVIDER: S-EPMC7466740 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature