A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies.

ABSTRACT: Individual age estimation can be applied to criminal, legal, and anthropological investigations. DNA methylation has been established as the biomarker of choice for age prediction, since it was observed that specific CpG positions in the genome show systematic changes during an individual's lifetime, with progressive increases or decreases in methylation levels. Subsequently, several forensic age prediction models have been reported, providing average age prediction error ranges of ±3-4 years, using a broad spectrum of technologies and underlying statistical analyses. DNA methylation assessment is not categorical but quantitative. Therefore, the detection platform used plays a pivotal role, since quantitative and semi-quantitative technologies could potentially result in differences in det

SUBMITTER: Freire-Aradas A 

PROVIDER: S-EPMC7466768 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature