Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8⁺ tissue-resident memory T cells in a miR-155-dependent fashion.

ABSTRACT:

Background

Brain inflammation is a key cause of cognitive decline after central nervous system (CNS) infections. A thorough understanding of immune responses to CNS infection is essential for developing anti-inflammatory interventions that improve outcomes. Tissue-resident memory T cells (T_RM) are non-recirculating memory T cells that provide surveillance of previously infected tissues. However, in addition to protecting the brain against reinfection, brain T_RM can contribute to post-infectious neuroinflammation. We hypothesized that accumulation of CD8⁺ T_RM in the brain could be reduced by inhibiting microRNA (miR)-155, a microRNA that influences development of cytotoxic CD8⁺ T lymphocytes during infection.

Methods

C57B

SUBMITTER: Cassidy BR 

PROVIDER: S-EPMC7466815 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature