MMP2 as an independent prognostic stratifier in oral cavity cancers.

ABSTRACT:

Background

Around 25% of oral cavity squamous cell carcinoma (OCSCC) are not controlled by the standard of care, but there is currently no validated biomarker to identify those patients. Our objective was to determine a robust biomarker for severe OCSCC, using a biology-driven strategy.

Patients and methods

Tumor and juxtatumor secretome were analyzed in a prospective discovery cohort of 37 OCSCC treated by primary surgery. Independent biomarker validation was performed by RTqPCR in a retrospective cohort of 145 patients with similar clinical features. An 18-gene signature (18 G) predictive of the response to PD-1 blockade was evaluated in the same cohort.

Results

Among 29 deregulated molecules identified in a secretome analysis, including chemokines, cytokines, growt

SUBMITTER: Hoffmann C 

PROVIDER: S-EPMC7466851 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature