Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy.

ABSTRACT: Accumulating evidence demonstrates the decisive role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade in preclinical tumor models, as well as in cancer patients. In synthesis, it appears that a normal intestinal microbiota supports therapeutic anticancer responses, while a dysbiotic microbiota that lacks immunostimulatory bacteria or contains overabundant immunosuppressive species causes treatment failure. These findings have led to the design of clinical trials that evaluate the capacity of modulation of the gut microbiota to synergize with treatment and hence limit tumor progression. Along the lines of this Trial Watch, we discuss the rationale for harnessing the gut microbiome in support of c

SUBMITTER: Daillere R 

PROVIDER: S-EPMC7466862 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature