Evaluation of Imaging Windows for Tau PET Imaging Using ¹⁸F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer's Disease Patients.

ABSTRACT:

Background

The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients, using ¹⁸F-PI 2620 dynamic PET acquisition.

Methods

Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal individuals were enrolled in this study. A dynamic ¹⁸F-PI 2620 PET study was conducted at 30-75 minutes post-injection in these groups. Co-registration was applied between the dynamic acquisition PET and T1-weighted MRI to delineate various cortical regions. The standardized uptake value ratio (SUVR) was used for quantitative analysis. P-mod software with the Automated Anatomical Labeling (AAL)-merged atlas was employed to generate automatic volumes of interest for

SUBMITTER: Chotipanich C 

PROVIDER: S-EPMC7466905 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature