Stability of misoprostol tablets collected in Malawi and Rwanda: Importance of intact primary packaging.

ABSTRACT: Misoprostol is listed in the WHO essential medicines list and can be used for induction of labour, for prevention and treatment of post-partum haemorrhage, and for abortions. The compound is unstable, and substandard misoprostol preparations have been detected in low- and middle-income countries. We now investigated the stability of misoprostol tablets according to the international guidelines for stability testing of pharmaceutical products. Three brands (four batches) of misoprostol tablets were collected in Malawi and Rwanda: the originator product, a WHO-prequalified product, and a generic product without WHO prequalification. A further batch of the originator product was collected in Germany. To investigate the effect of damage to the primary packaging, additional blister strips of on

SUBMITTER: Hagen N 

PROVIDER: S-EPMC7467217 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature