Safety range of free valproic acid serum concentration in adult patients.

ABSTRACT:

Background

Therapeutic drug monitoring (TDM) is recommended during valproic acid (VPA) use, and total serum concentration has been widely adopted. However, the free form of VPA is responsible for its pharmacologic and toxic effects, and the total and free concentrations are highly discordant because of VPA's highly protein bound and saturable binding characteristics. Therefore, free VPA monitoring is increasingly advocated. Nevertheless, the correlation between free VPA concentration and associated adverse effects remains unknown.

Objective

To determine the optimal safety range of free VPA concentration in adult patients.

Materials and methods

This prospective cohort study enrolled adult patients undergoing VPA therapy with TDM. Patient characteristics, VPA use, and a

SUBMITTER: Tseng YJ 

PROVIDER: S-EPMC7467252 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature