Muscle weakness has a limited effect on motor control of gait in Duchenne muscular dystrophy.

ABSTRACT:

Aim

Our aim was to determine if synergy weights and activations are altered in Duchenne muscular dystrophy (DMD) and if these alterations could be linked to muscle weakness.

Methods

In 22 children with DMD and 22 typical developing (TD) children of a similar age, surface electromyography (sEMG) of the gluteus medius, rectus femoris (REF), medial hamstrings, tibialis anterior, and medial gastrocnemius (GAS) were recorded during gait. Muscle weakness was assessed with maximal voluntary isometric contractions (MVIC). Synergies were calculated with non-negative matrix factorization. The number of synergies explaining ≥90% of the variance in the sEMG signals (N90), were extracted and grouped with k-means cluster analysis. We verified differences in weights with a Mann-Whitney U t

SUBMITTER: Vandekerckhove I 

PROVIDER: S-EPMC7467330 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature