Transcriptome analysis of mouse aortae reveals multiple novel pathways regulated by aging.

ABSTRACT: Vascular aging has been documented as a vital process leading to arterial dysfunction and age-related cardiovascular and cerebrovascular diseases. However, our understanding of the molecular underpinnings of age-related phenotypes in the vascular system is incomplete. Here we performed bulk RNA sequencing in young and old mouse aortae to elucidate age-associated changes in the transcriptome. Results showed that the majority of upregulated pathways in aged aortae relate to immune response, including inflammation activation, apoptotic clearance, and phagocytosis. The top downregulated pathway in aged aortae was extracellular matrix organization. Additionally, protein folding control and stress response pathways were downregulated in the aged vessels, with an array of downregulated genes enco

SUBMITTER: Gao P 

PROVIDER: S-EPMC7467355 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature