The impact of folate and vitamin B12 status on cognitive function and brain atrophy in healthy elderly and demented Austrians, a retrospective cohort study.

ABSTRACT:

Background

Dementia, and in particular Alzheimer's disease (AD), is a debilitating progressive disease with high prevalence in our society. Vitamin B12 and folate deficiency are potential modifiable risk factors. However, previous studies reported inconsistent results.

Results

The average concentrations of all biochemical markers were within the respective reference ranges. Cross-sectional and longitudinal analyses did not reveal significant associations between biochemical markers and cognitive function, global or regional brain volume, cortical thickness or cortical surface area, neither in controls nor in AD patients.

Conclusions

Variations of direct and indirect markers of B12 and folate status are not associated with cognitive dysfunction and brain atrophy.

Me

SUBMITTER: Rabensteiner J 

PROVIDER: S-EPMC7467363 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature