Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study.

ABSTRACT: Metabolomics provides a promising tool for understanding the pathophysiology and identifying biomarkers of atherosclerosis. We aimed to estimate the associations between circulating metabolites and subclinical atherosclerosis in a Chinese cohort. The baseline serum levels of 38 metabolites of 489 individuals were measured using nuclear magnetic resonance. Associations between metabolites and brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT) were determined using a linear regression. A multivariate logistic regression was used to evaluate the associations of metabolites and subclinical atherosclerosis defined as high baPWV (>median) and increased IMT (>median). After adjusting for covariates and multiple testing corrections (false discovery rate; FDR), two

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC7467377 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature