Comparative Efficacy of Cabozantinib and Regorafenib for Advanced Hepatocellular Carcinoma.

ABSTRACT:

Background

No trials have compared cabozantinib and regorafenib for the second-line treatment of advanced hepatocellular carcinoma (HCC).

Objectives

Conduct a matching-adjusted indirect comparison (MAIC) of the efficacy and safety of second-line cabozantinib and regorafenib in patients with advanced HCC and disease progression after prior sorafenib.

Methods

The CELESTIAL and RESORCE trials were used for indirect comparison of second-line cabozantinib and regorafenib in advanced HCC. Population-level data were available for RESORCE, individual patient data (IPD) for CELESTIAL. To align with RESORCE, the CELESTIAL population was limited to patients who received first-line sorafenib only. To minimize potential effect-modifying population differences, the CELESTIAL IPD we

SUBMITTER: Kelley RK 

PROVIDER: S-EPMC7467441 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature