Association between urinary biomarkers and disease progression in adults with autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

Height-adjusted total kidney volume (htTKV) is considered as the best predictor of kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD), but its limited predictive capacity stresses the need to find new biomarkers of ADPKD progression. The aim of this study was to investigate urinary biomarkers of ADPKD progression.

Methods

This observational study included ADPKD patients, and two comparator groups of ischaemic and non-ischaemic kidney injury: benign nephroangiosclerosis patients and non-ischaemic chronic kidney disease (CKD) patients. Proteinuria, htTKV and urinary levels of molecules are associated with ischaemia and/or tubular injury. The slope of estimated glomerular filtration rate (eGFR) was used as a dependent variable in un

SUBMITTER: Segarra-Medrano A 

PROVIDER: S-EPMC7467584 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature