Properties of Aqueous Trehalose Mixtures: Glass Transition and Hydrogen Bonding.

ABSTRACT: Trehalose is a naturally occurring disaccharide known to remarkably stabilize biomacromolecules in the biologically active state. The stabilizing effect is typically observed over a large concentration range and affects many macromolecules including proteins, lipids, and DNA. Of special interest is the transition from aqueous solution to the dense and highly concentrated glassy state of trehalose that has been implicated in bioadaptation of different organisms toward desiccation stress. Although several mechanisms have been suggested to link the structure of the low water content glass with its action as an exceptional stabilizer, studies are ongoing to resolve which are most pertinent. Specifically, the role that hydrogen bonding plays in the formation of the glass is not well resolved. H

SUBMITTER: Olgenblum GI 

PROVIDER: S-EPMC7467637 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature