Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population.

ABSTRACT:

Background

Keloids represent chronic fibroproliferative skin disorders in which there is deposition of extracellular components, especially type 1 collagen, fibronectin and elastin, in excessive amounts. NEDD4 is associated with fibrosis found in abnormal wound healing through increased fibroblast proliferation and regulation of type 1 collagen expression. The exact etiology of keloid formation is undefined, but the role of genetic factors was demonstrated.

Objective

To investigate the polymorphism of the NEDD4 gene rs8032158 in a sample of Egyptian patients who have keloids.

Methods

The current case-control study was conducted in 160 unrelated subjects; 100 keloid patients and 60 ages and sex coincided with apparently healthy controls. All subjects underwent a comple

SUBMITTER: Farag AGA 

PROVIDER: S-EPMC7467735 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature