Lipophilic Arginine Esters: The Gateway to Preservatives without Side Effects.

ABSTRACT: This study hypothesized that long carbon chain cationic arginine (Arg) esters can be considered as toxicologically harmless preservatives. Arg-esters with C₁₈ and C₂₄ carbon chains, namely, arginine-oleate (Arg-OL) and arginine-decyltetradecanoate (Arg-DT), were synthesized. Structures were confirmed by FT-IR, ¹H NMR, and mass spectroscopy. Both Arg-esters were tested regarding hydrophobicity in terms of log P_{octanol/water}, critical micelle concentration (CMC), biodegradability, cytotoxicity, hemolysis, and antimicrobial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), and Enterococcus <

SUBMITTER: Shahzadi I 

PROVIDER: S-EPMC7467771 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature