The First Total Synthesis of the Lipid Mediator PD2_n-3 DPA.

ABSTRACT: The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2_n-3 DPA is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2_n-3 DPA is presented.

SUBMITTER: Tungen JE 

PROVIDER: S-EPMC7467816 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature