Detection of antibodies against SARS-CoV-2 spike protein by gold nanospikes in an opto-microfluidic chip.

ABSTRACT: The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to active research in its associated diagnostics and medical treatments. While quantitative reverse transcription polymerase chain reaction (qRT-PCR) is the most reliable method to detect viral genes of SARS-CoV-2, serological tests for specific antiviral antibodies are also important as they identify false negative qRT-PCR responses, track how effectively the patient's immune system is fighting the infection, and are potentially helpful for plasma transfusion therapies. In this work, based on the principle of localized surface plasmon resonance (LSPR), we develop an opto-microfluidic sensing platform with gold nanospikes, fabricated by electrodeposition, to detect the presence and amount of

SUBMITTER: Funari R 

PROVIDER: S-EPMC7467868 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature