Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer.

ABSTRACT:

Background

Limited treatment options are available in chemotherapy-refractory metastatic colorectal cancer (mCRC). The objective was to conduct a systematic literature review (SLR) and exploratory network meta-analysis (NMA) to compare the tolerability and effectiveness of SIRT with Y-90 resin microspheres, regorafenib, TAS-102 (trifluridine/tipiracil), and best supportive care (BSC) as third-line treatment in patients with mCRC.

Methods

An SLR was conducted to identify studies comparing two or more of the treatments and reporting overall survival (OS), progression-free survival, tumor response, or adverse event (AE) incidence. An exploratory NMA was conducted to compare hazard ratios (HRs) for OS using Markov chain Monte Carlo (MCMC) techniques.

Results

Seven studies

SUBMITTER: Walter T 

PROVIDER: S-EPMC7467965 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature