Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

ABSTRACT:

Purpose

Canonical Wnt/ β-catenin pathway is one mechanism being activated in platinum-resistant epithelial ovarian cancer (EOC). Detecting potential targets for Wnt pathway modulation as a putative future therapeutic approach was the aim of this study.

Methods

Biological effects of different Wnt modulators (SB216763, XAV939 and triptolide) on the EOC cell lines A2780 and its platinum-resistant clone A2780cis were investigated via multiple functional tests. Immunohistochemistry (IHC) was carried out to compare the expression levels of Wnt marker proteins (β-catenin, snail/ slug, E-cadherin) in patient specimens and to correlate them with lifetime data.

Results

We could show that activated Wnt signaling of the platinum-resistant EOC cell line A2780cis can be reversed by

SUBMITTER: Kaltofen T 

PROVIDER: S-EPMC7467966 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature