Mitochondrial oxygen consumption rate of human embryos declines with maternal age.

ABSTRACT:

Purpose

The fertility of women decreases with age because of factors such as an increased incidence of aneuploidies and-possibly-decreased mitochondrial activity in oocytes. However, the relationship between maternal aging and mitochondrial function of their embryos remains unknown. Here, we assessed the relationship between maternal age and mitochondrial functions in their oocytes and embryos METHODS: The relationships between maternal age and oxygen consumption rates (OCRs), mitochondrial DNA (mtDNA) copy numbers, or blastocyst development was investigated using 81 embryos donated from 63 infertility couples. The developmental rates from morulae to blastocysts were retrospectively analyzed using data of 105 patients.

Results

The OCRs of morulae decreased with maternal age

SUBMITTER: Morimoto N 

PROVIDER: S-EPMC7467997 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature