GnRH triggering may improve euploidy and live birth rate in hyper-responders: a retrospective cohort study.

ABSTRACT:

Purpose

Despite the increasing use of GnRHa to trigger final oocyte maturation in segmented IVF cycles, the effects of trigger modality on chromosomal competence and embryo quality remain controversial. Hence, the purpose of this study was to compare euploidy rates and pregnancy outcomes among hyper-responding women using hCG versus GnRHa trigger.

Methods

This retrospective study included 333 hyper-responders, defined as >15 oocytes retrieved, who underwent preimplantation genetic testing (PGT-A) in segmented IVF cycles using either GnRHa or urinary hCG trigger. Live birth rate (LBR) was the primary outcome of interest. Implantation rate (IR), clinical pregnancy rate (CPR), and euploidy rate were secondary outcomes.

Results

GnRH triggering was associated with improved

SUBMITTER: Tan J 

PROVIDER: S-EPMC7468004 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature