Folic acid supplementation regulates key immunity-associated genes and pathways during the periparturient period in dairy cows.

ABSTRACT:

Objective

The current research was aimed to profile the transcriptomic picture of the peripheral blood lymphocytes (PBLs) associated with immunity in Chinese Holsteins supplemented orally with coated folic acid during the periparturient period.

Methods

The total of 123 perinatal cows were selected for this study and divided into three groups; group A (n = 41, 240mg/ 500 kg cow/day), group B (n = 40, 120mg/ 500 kg cow/day) and group C (n = 42, 0mg/cow/day) based on the quantity of folic acid fed. Three samples of PBLs were selected from each folic acid treated group (High, Low, and Control) and RNA sequencing method was carried out for transcriptomic analysis.

Results

The analysis revealed that a higher number of genes and pathways were regulated in response to high an

SUBMITTER: Khan MZ 

PROVIDER: S-EPMC7468170 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature