Myeloid-Derived Suppressor Cells Promote the Progression of Primary Membranous Nephropathy by Enhancing Th17 Response.

ABSTRACT: Several studies have confirmed that the myeloid-derived suppressor cells (MDSCs) are closely associated with autoimmune diseases, but their exact role in these processes remains largely unclear. Here, we investigated the role MDSCs in patients with primary membranous nephropathy (PMN). Compared to healthy controls (HCs), PMN patients showed significantly increased number of HLA-DR^-CD11b⁺CD33⁺ MDSCs in the peripheral blood, including both CD14⁺CD66b^- monocytic and CD14^-CD66b⁺ granulocytic MDSCs. The frequency of MDSCs was positively correlated with the level of serum anti-phospholipase A2 receptor (anti-PLA2R), 24-h urine protein quantification, and disease activity in PMN patients. Consistently, enhanced T helper

SUBMITTER: Li H 

PROVIDER: S-EPMC7468481 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature