Neurophysiological and Genetic Findings in Patients With Juvenile Myoclonic Epilepsy.

ABSTRACT:

Objective

Transcranial magnetic stimulation (TMS), a non-invasive procedure, stimulates the cortex evaluating the central motor pathways. The response is called motor evoked potential (MEP). Polyphasia results when the response crosses the baseline more than twice (zero crossing). Recent research shows MEP polyphasia in patients with generalized genetic epilepsy (GGE) and their first-degree relatives compared with controls. Juvenile Myoclonic Epilepsy (JME), a GGE type, is not well studied regarding polyphasia. In our study, we assessed polyphasia appearance probability with TMS in JME patients, their healthy first-degree relatives and controls. Two genetic approaches were applied to uncover genetic association with polyphasia.

Methods

20 JME patients, 23 first-degree relati

SUBMITTER: Stefani S 

PROVIDER: S-EPMC7468511 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature