NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.

ABSTRACT: Stringent regulation of the chondrocyte cell cycle is required for endochondral bone formation. During the longitudinal growth of long bones, mesenchymal stem cells condense and differentiate into chondrocytes. Epiphyseal chondrocytes sequentially differentiate to form growth- plate cartilage, which is subsequently replaced with bone. Although the importance of nuclear factor 1C (Nfic) in hard tissue formation has been extensively studied, knowledge regarding its biological roles and molecular mechanisms in this process remains insufficient. Herein, we demonstrated that Nfic deficiency affects femoral growth-plate formation. Chondrocyte proliferation was downregulated and the number of apoptotic cell was increased in the growth plates of Nfic^-/- mice. Further, the express

SUBMITTER: Lee DS 

PROVIDER: S-EPMC7468589 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature