The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome.

ABSTRACT: There is considerable interest in the trace element selenium as a possible cancer chemopreventive dietary component, but supplementation trials have not indicated a clear benefit. Selenium is a critical component of selenium-containing proteins, or selenoproteins. Members of this protein family contain selenium in the form of selenocysteine. Selenocysteine is encoded by an in-frame UGA codon recognized as a selenocysteine codon by a regulatory element, the selenocysteine insertion sequence (SECIS), in the 3'-untranslated region of selenoprotein mRNAs. Epidemiological studies have implicated several selenoprotein genes in cancer risk or outcome based on associations between allelic variations and disease risk or mortality. These polymorphisms can be found in or near the SECIS or in the sele

SUBMITTER: Kadkol S 

PROVIDER: S-EPMC7468715 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature