Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis.

ABSTRACT: Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried's phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and t

SUBMITTER: Marcos-Perez D 

PROVIDER: S-EPMC7469050 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature