Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies.

ABSTRACT: In the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) both at the regional and cellular level. Recently, it was shown that intracellular tau pathology causes GVB formation in experimental models thus explaining the strong correlation between these neuropathological hallmarks in the human brain. These novel models of GVB formation provide opportunities for future research into GVB biology, but also urge reevaluation of previous post-mortem observations. Here, we review neuropathological data on GVBs in tauopathies and other neurodegenerative proteinopathies. We discuss the possibility that intracellular aggregates composed of proteins other than tau are also able to induce GVB formation. Furthermore, the potential mechan

SUBMITTER: Wiersma VI 

PROVIDER: S-EPMC7469111 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature