ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals.

ABSTRACT:

Background

Immunologic aging leads to immune dysfunction, significantly reducing the quality of life of the elderly. Aged-related defects in early hematopoiesis result in reduced lymphoid cell development, functionally defective mature immune cells, and poor protective responses to vaccines and pathogens. Despite considerable progress understanding the underlying causes of decreased immunity in the elderly, the mechanisms by which these occur are still poorly understood. The DNA-binding protein ARID3a is expressed in a subset of human hematopoietic progenitors. Inhibition of ARID3a in bulk human cord blood CD34⁺ hematopoietic progenitors led to developmental skewing toward myeloid lineage at the expense of lymphoid lineage cells in vitro. Effects of ARID3a expression in

SUBMITTER: Ratliff ML 

PROVIDER: S-EPMC7469297 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature