Association between NPPA promoter methylation and hypertension: results from Gusu cohort and replication in an independent sample.

ABSTRACT:

Background

Atrial natriuretic peptide (ANP), one of the main members of the natriuretic peptides system, has been associated with hypertension and related complications, but the underlying molecular mechanisms are not very clear. Here, we aimed to examine whether DNA methylation, a molecular modification to the genome, of the natriuretic peptide A gene (NPPA), the coding gene of ANP, was associated with hypertension.

Methods

Peripheral blood DNA methylation of NPPA promoter was quantified by target bisulfite sequencing in 2498 community members (mean aged 53 years, 38% men) as a discovery sample and 1771 independent participants (mean aged 62 years, 54% men) as a replication sample. In both samples, we conducted a single CpG association analysis, followed by a gene-based ass

SUBMITTER: Li J 

PROVIDER: S-EPMC7469321 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature