SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis.

ABSTRACT:

Background

Astrocytoma is a common tumor type in primary central nervous system and has a high death rate around the world. Aberrant expression of long non-coding RNAs (lncRNAs) has been introduced by emerging studies to result in the development of diverse cancers.

Methods

RT-qPCR examined the expression of SNHG17, miR-876-5p and ERLIN2, and western blot evaluated ERLIN2 protein level. RNA pull down and luciferase reporter assays illustrated the relationships between SNHG17 and its downstream molecules.

Results

SNHG17 was up-regulated in astrocytoma cells. Moreover, SNHG17 silence could repress the proliferation, migration and invasion of astrocytoma cells. Besides, miR-876-5p was selected out as a downstream molecule of SNHG17 in astrocytoma. ERLIN2 was determined t

SUBMITTER: Du F 

PROVIDER: S-EPMC7469335 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature