Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.

ABSTRACT:

Background

Identifying and understanding the functional role of genetic risk factors for Alzheimer disease (AD) has been complicated by the variability of genetic influences across brain regions and confounding with age-related neurodegeneration.

Methods

A gene co-expression network was constructed using data obtained from the Allen Brain Atlas for multiple brain regions (cerebral cortex, cerebellum, and brain stem) in six individuals. Gene network analyses were seeded with 52 reproducible (i.e., established) AD (RAD) genes. Genome-wide association study summary data were integrated with the gene co-expression results and phenotypic information (i.e., memory and aging-related outcomes) from gene knockout studies in Drosophila to generate rankings for other genes that may hav

SUBMITTER: Lancour D 

PROVIDER: S-EPMC7469336 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature