Trichinella spiralis co-infection exacerbates Plasmodium berghei malaria-induced hepatopathy.

ABSTRACT:

Background

Although Plasmodium parasites and intestinal helminths share common endemic areas, the mechanisms of these co-infections on the host immune response remain not fully understood. Liver involvement in severe Plasmodium falciparum infections is a significant cause of morbidity and mortality. However, the effect of pre-existing Trichinella spiralis infection on the immune response and liver immune-pathogenesis in P. berghei ANKA (PbANKA)-infected mice needs to be elucidated.

Methods

Outbred Kunming mice were infected with T. spiralis and 9 days later were challenged with P. berghei ANKA (PbANKA), and the investigation occurred at 13 days after co-infection.

Results

Compared with PbANKA-mono-infected mice, T. spiralis + PbANKA-co-infected mice had similar surviv

SUBMITTER: Mei X 

PROVIDER: S-EPMC7469358 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature