Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis.

ABSTRACT: An extension of the G1 is correlated with stem cell differentiation. The role of cell cycle regulation during the subsequent transit amplification (TA) divisions is, however, unclear. Here, we report for the first time that in the Drosophila male germline lineage, the transit amplification divisions accelerate after the second TA division. The cell cycle phases, marked by Cyclin E and Cyclin B, are progressively altered during the TA. Antagonistic functions of the bag-of-marbles and the Transforming-Growth-Factor-β signaling regulate the cell division rates after the second TA division and the extent of the Cyclin E phase during the fourth TA division. Furthermore, loss of Cyclin E during the fourth TA cycle retards the cell division and induces premature meiosis in some case

SUBMITTER: Gadre P 

PROVIDER: S-EPMC7469542 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature