Cellular expression profiles of Epstein-Barr virus-transformed B-lymphoblastoid cell lines.

ABSTRACT: Epstein-Barr virus (EBV) can infect human B cells and is associated with various types of B cell lymphomas. Studies on the global alterations of the cellular pathways mediated by EBV-induced B cell transformation are limited. In the present study, microarray analysis was performed following generation of two EBV-infected B-lymphoblastoid cell lines (BLCL), in which normal B cells obtained from two healthy Thai individuals and transcriptomic profiles were compared with their respective normal B cells. The two EBV-transformed BLCL datasets exhibited a high degree of similarity between their RNA expression profiles, whereas the two normal B-cell datasets did not exhibit the same degree of similarity in their RNA expression profiles. Differential gene expression analysis was performed, and the

SUBMITTER: Chaiwongkot A 

PROVIDER: S-EPMC7469576 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature